SEMA6C

Across TCGA patient cohorts, SEMA6C mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA6C-associated genes across cancer lineages are Caspase-7-cleavedD198, C-Raf, and A-Raf_pS299. Each is linked with SEMA6C in more than 2 cancer types. Because this analysis shows association rather than direction, both SEMA6C-to-partner and partner-to-SEMA6C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SEMA6C-low versus SEMA6C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA6C→partner) and Y-score (partner→SEMA6C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.990	+1.604	<.001	.021	3	3
UCEC	C-Raf →	+0.212	+3.459	<.001	.005	3	2
UCEC	A-Raf_pS299 →	-0.162	-2.247	<.001	.001	3	2
UCEC	N-Cadherin →	+0.196	+2.321	.011	.033	3	2
UCEC	PCNA →	+0.240	+1.584	.002	.034	3	2
UCEC	STAT3_pY705 →	-0.314	-2.115	.001	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Caspase-7-cleavedD198 by SEMA6C expression — UCEC

Explore this box plot interactively →