SEMA6C

Across TCGA cell cohorts, SEMA6C RNA expression is significantly associated with the go_rna of many other GO terms, with 5,542 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SEMA6C-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Positive regulation of DNA repair, and Negative regulation of myoblast fusion. Each is linked with SEMA6C in more than 15 cancer types. Because this analysis shows association rather than direction, both SEMA6C-to-partner and partner-to-SEMA6C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by SEMA6C-low versus SEMA6C-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA6C→partner) and Y-score (partner→SEMA6C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.175	+1.813	<.001	<.001	3	16
BONE	Positive regulation of DNA repair →	+0.072	+1.661	<.001	<.001	3	15
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.176	+1.813	<.001	<.001	3	15
BONE	Positive regulation of double-strand break repair via homologous recombination →	+0.090	+1.415	.001	.003	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.162	+0.929	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Regulation of RNA splicing →	+0.086	+0.826	<.001	.006	2	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,542 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by SEMA6C expression — OESOPHAGUS

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