SEMA6C

Across TCGA cell cohorts, SEMA6C mutation is significantly associated with the RNA expression of many other genes, with 680 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEMA6C-associated genes across cancer lineages are ADAM2, PRSS58, and LRIT2. Each is linked with SEMA6C in more than 2 cancer types. Because this analysis shows association rather than direction, both SEMA6C-to-partner and partner-to-SEMA6C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM2 grouped by SEMA6C-low versus SEMA6C-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA6C→partner) and Y-score (partner→SEMA6C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ADAM2 →	+0.350	+2.675	.002	.006	3	3
PANCREAS	PRSS58 →	+0.092	+5.000	<.001	.006	3	2
LUNG_NSCLC_LUAD	LRIT2 →	+0.029	+4.887	<.001	.009	3	2
BLOOD_Leukemia	CENPM →	+0.905	+3.730	<.001	<.001	3	2
BLOOD_Leukemia	ABHD17B →	+0.994	+3.260	<.001	.005	3	2
BLOOD_Leukemia	PSMD9 →	+0.499	+3.730	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 680 associations by consensus.

ADAM2 by SEMA6C expression — OVARY

Explore this box plot interactively →