SEMA5B

Across TCGA pan-cancer cohorts, SEMA5B mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SEMA5B data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SEMA5B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SEMA5B expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

CCRCC and GBM are the cancer types where SEMA5B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	IV	0.451	1.000	.016	5	view →
GBM	DFS	Median	All	0.839	0.652	.015	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SEMA5B–CCRCC (OS)

Open the CCRCC breakdown →