Across TCGA patient cohorts, SEMA4D RNA expression is significantly associated with the protein abundance of many other proteins, with 15,363 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SEMA4D-associated proteins across cancer lineages are SASH3, SEMA4D_S788, and SEPTIN6. Each is linked with SEMA4D in more than 6 cancer types. Because this analysis shows association rather than direction, both SEMA4D-to-partner and partner-to-SEMA4D results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4D→partner) and Y-score (partner→SEMA4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SASH3 →	+0.463	+0.588	<.001	<.001	3	7
LSCC	SEMA4D_S788 →	+0.793	+0.620	<.001	<.001	3	7
GBM	SEPTIN6 →	+0.548	+0.792	<.001	<.001	3	7
HNSC	FNBP1 →	+0.441	+0.761	<.001	<.001	3	7
BRCA	ARHGAP25 →	+0.550	+0.667	<.001	<.001	3	6
BRCA	INPP4A →	+0.270	+0.722	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,363 associations by consensus.

Exploration

SEMA4D survival (RNA) · tumor vs normal (RNA) · all SEMA4D data types