Across TCGA patient cohorts, SEMA4D mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA4D-associated genes across cancer lineages are eEF2, Caspase-7-cleavedD198, and GAPDH. Each is linked with SEMA4D in more than 3 cancer types. Because this analysis shows association rather than direction, both SEMA4D-to-partner and partner-to-SEMA4D results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4D→partner) and Y-score (partner→SEMA4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eEF2 →	+0.459	+3.000	.015	.036	3	4
UCEC	Caspase-7-cleavedD198 →	+0.760	+1.584	<.001	.032	3	4
UCEC	GAPDH →	+0.520	+3.459	.003	.005	3	3
UCEC	p62 Lck ligand →	+0.378	+2.201	<.001	<.001	3	3
UCEC	c-Met_pY1235 →	+0.061	+1.916	.014	.009	3	3
UCEC	eIF4E →	+0.173	+2.584	.014	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration

SEMA4D survival (RNA) · tumor vs normal (RNA) · all SEMA4D data types