Across TCGA cell cohorts, SEMA4D RNA expression is significantly associated with the go_rna of many other GO terms, with 4,917 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEMA4D-associated GO terms across cancer lineages are Regulation of inhibitory synapse assembly, Positive regulation of inhibitory synapse assembly, and Recombinational repair. Each is linked with SEMA4D in more than 17 cancer types. Because this analysis shows association rather than direction, both SEMA4D-to-partner and partner-to-SEMA4D results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4D→partner) and Y-score (partner→SEMA4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of inhibitory synapse assembly →	+1.196	+2.074	.003	<.001	3	18
LUNG_NSCLC_LUSC	Positive regulation of inhibitory synapse assembly →	+1.322	+2.358	<.001	<.001	3	18
BONE	Recombinational repair →	+0.099	+1.548	.004	.002	3	13
OESOPHAGUS	Cilium or flagellum-dependent cell motility →	-0.096	-1.319	<.001	<.001	3	12
BONE	Positive regulation of double-strand break repair →	+0.084	+1.322	.001	.004	3	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of collateral sprouting →	+0.943	+1.044	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,917 associations by consensus.

Exploration

SEMA4D survival (RNA) · tumor vs normal (RNA) · all SEMA4D data types