Across TCGA cell cohorts, SEMA4D mutation is significantly associated with the RNA expression of many other genes, with 436 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEMA4D-associated genes across cancer lineages are CER1, FADS6, and DPPA3. Each is linked with SEMA4D in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMA4D-to-partner and partner-to-SEMA4D results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4D→partner) and Y-score (partner→SEMA4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CER1 →	+0.017	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	FADS6 →	+0.023	+3.843	.006	.007	3	1
BLOOD_Lymphoma	DPPA3 →	+0.012	+4.662	<.001	.003	3	1
BLOOD_Lymphoma	SPP2 →	+0.572	+4.662	<.001	.003	3	1
LARGE_INTESTINE	GCAT →	+1.222	+2.502	.001	.005	3	1
LARGE_INTESTINE	EIF3L →	+0.528	+3.389	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 436 associations by consensus.

Exploration

SEMA4D survival (RNA) · tumor vs normal (RNA) · all SEMA4D data types