Across TCGA patient cohorts, SEMA4B RNA expression is significantly associated with the protein abundance of many other proteins, with 12,526 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible SEMA4B-associated proteins across cancer lineages are MKNK2_S220, SEMA4B_S803, and ERO1A. Each is linked with SEMA4B in more than 5 cancer types. Because this analysis shows association rather than direction, both SEMA4B-to-partner and partner-to-SEMA4B results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4B→partner) and Y-score (partner→SEMA4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MKNK2_S220 →	+0.759	+0.933	<.001	<.001	3	5
LUAD	SEMA4B_S803 →	+1.773	+1.444	<.001	<.001	3	5
PDAC	ERO1A →	+0.760	+0.784	<.001	<.001	2	6
UCEC	SLC16A3 →	+0.501	+0.566	.007	.008	3	5
PDAC	TPI1_S80 →	+0.591	+0.783	.001	<.001	3	5
BRCA	ARHGEF2 →	-0.243	-0.610	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,526 associations by consensus.

Exploration

SEMA4B survival (RNA) · tumor vs normal (RNA) · all SEMA4B data types