Across TCGA patient cohorts, SEMA4B protein abundance is significantly associated with the RNA expression of many other genes, with 11,338 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SEMA4B-associated genes across cancer lineages are RPS12P26, CIB1, and PLCL1. Each is linked with SEMA4B in more than 6 cancer types. Because this analysis shows association rather than direction, both SEMA4B-to-partner and partner-to-SEMA4B results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4B→partner) and Y-score (partner→SEMA4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPS12P26 →	+1.231	+0.541	<.001	<.001	3	7
LSCC	CIB1 →	+0.655	+0.737	<.001	<.001	3	7
CCRCC	PLCL1 →	-0.587	-0.329	.004	.006	3	6
HNSC	ERO1A →	+0.716	+0.386	<.001	<.001	3	6
LSCC	ANKRD44 →	-0.587	-0.616	<.001	<.001	3	6
UCEC	EGLN3 →	+1.270	+0.272	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,338 associations by consensus.

Exploration

SEMA4B survival (RNA) · tumor vs normal (RNA) · all SEMA4B data types