SEMA4B

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SEMA4B mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA4B-associated genes across cancer lineages are eIF4E, Notch1, and Rictor_pT1135. Each is linked with SEMA4B in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMA4B-to-partner and partner-to-SEMA4B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4B→partner) and Y-score (partner→SEMA4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECeIF4E →+0.189+3.000.030.00132
UCECNotch1 →+0.141+1.807.015.02732
UCECRictor_pT1135 →-0.109-2.321.010.00632
UCECCaspase-7-cleavedD198 →+0.712+2.321.003.00632
UCECC-Raf →+0.238+3.807<.001<.00132
UCECDvl3 →+0.240+2.584.001.01032
Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

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