Across TCGA cell cohorts, SEMA4B mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEMA4B-associated genes across cancer lineages are GSC2, OR1L6, and C2orf80. Each is linked with SEMA4B in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMA4B-to-partner and partner-to-SEMA4B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4B→partner) and Y-score (partner→SEMA4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSC2 →	+0.086	+2.688	<.001	.008	3	2
BONE	OR1L6 →	+0.020	+5.169	<.001	.004	3	1
BONE	C2orf80 →	+0.126	+5.169	<.001	.004	3	1
LARGE_INTESTINE	S100G →	+1.151	+4.273	<.001	<.001	3	1
LARGE_INTESTINE	CEACAM3 →	+0.595	+3.295	<.001	.009	3	1
LARGE_INTESTINE	TFDP3 →	+0.015	+2.933	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

SEMA4B survival (RNA) · tumor vs normal (RNA) · all SEMA4B data types