Across TCGA pan-cancer cohorts, SEMA4A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SEMA4A data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SEMA4A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEMA4A expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where SEMA4A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.906	0.992	.010	8	view →
LUAD	OS	Median	III,IV	0.334	0.760	.005	7	view →
PDAC	OS	Quartile	All	0.284	0.584	.009	5	view →
CCRCC	DFS	Median	II,III,IV	0.720	0.437	.020	3	view →
LSCC	DFS	Quartile	All	1.000	0.267	.004	3	view →
GBM	OS	Quartile	All	0.993	0.801	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: SEMA4A tumor-vs-normal RNA expression · all SEMA4A data types