Across TCGA patient cohorts, SEMA4A protein abundance is significantly associated with the RNA expression of many other genes, with 15,497 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SEMA4A-associated genes across cancer lineages are CSF2RB, CD38, and JAML. Each is linked with SEMA4A in more than 7 cancer types. Because this analysis shows association rather than direction, both SEMA4A-to-partner and partner-to-SEMA4A results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4A→partner) and Y-score (partner→SEMA4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CSF2RB →	+1.178	+0.574	<.001	<.001	3	8
BRCA	CD38 →	+1.458	+0.585	<.001	<.001	3	8
OV	JAML →	+1.179	+0.731	<.001	.002	3	7
UCEC	LST1 →	+0.974	+0.563	<.001	<.001	3	7
HNSC	EBI3 →	+0.820	+0.363	<.001	<.001	3	7
HNSC	ZNF831 →	+0.928	+0.466	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,497 associations by consensus.

Exploration

SEMA4A survival (RNA) · tumor vs normal (RNA) · all SEMA4A data types