Across TCGA patient cohorts, SEMA4A mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA4A-associated genes across cancer lineages are eEF2, Rad50, and ATM. Each is linked with SEMA4A in more than 2 cancer types. Because this analysis shows association rather than direction, both SEMA4A-to-partner and partner-to-SEMA4A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4A→partner) and Y-score (partner→SEMA4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.294	+2.999	.032	.035	3	2
UCEC	Rad50 →	-0.195	-1.678	.036	.023	3	2
UCEC	ATM →	-0.406	-2.584	.019	.001	3	2
COAD	CDK1_pY15 →	+0.311	+2.825	.010	.035	3	1
COAD	4E-BP1 →	+0.443	+2.815	<.001	.036	1	3
UCEC	14-3-3_beta →	-0.090	-3.432	.020	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

SEMA4A survival (RNA) · tumor vs normal (RNA) · all SEMA4A data types