Across TCGA cell cohorts, SEMA4A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,376 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SEMA4A-associated GO terms across cancer lineages are Positive regulation of excitatory synapse assembly, Response to indole-3-methanol, and Cellular response to indole-3-methanol. Each is linked with SEMA4A in more than 18 cancer types. Because this analysis shows association rather than direction, both SEMA4A-to-partner and partner-to-SEMA4A results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4A→partner) and Y-score (partner→SEMA4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Positive regulation of excitatory synapse assembly →	+1.845	+4.909	<.001	<.001	3	19
URINARY_TRACT	Response to indole-3-methanol →	+0.202	+2.246	<.001	<.001	3	9
LUNG_NSCLC_LUAD	Cellular response to indole-3-methanol →	+0.183	+1.304	<.001	<.001	3	8
BONE	Activation of GTPase activity →	+0.088	+0.777	.001	.002	3	8
URINARY_TRACT	T cell mediated immunity →	+0.199	+2.395	.005	.003	2	9
URINARY_TRACT	G protein-coupled purinergic nucleotide receptor signaling pathway →	+1.327	+2.482	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,376 associations by consensus.

Exploration

SEMA4A survival (RNA) · tumor vs normal (RNA) · all SEMA4A data types