Across TCGA cell cohorts, SEMA4A mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEMA4A-associated genes across cancer lineages are GPR101, C9, and KRTAP6-1. Each is linked with SEMA4A in more than 2 cancer types. Because this analysis shows association rather than direction, both SEMA4A-to-partner and partner-to-SEMA4A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4A→partner) and Y-score (partner→SEMA4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GPR101 →	+0.085	+3.381	<.001	.002	3	3
LUNG_SCLC	C9 →	+0.145	+4.256	<.001	.002	3	2
SKIN	KRTAP6-1 →	+0.100	+6.022	<.001	.001	3	2
PANCREAS	GSTA3 →	+0.025	+5.000	<.001	.006	3	1
PANCREAS	OPCML →	+0.006	+5.000	<.001	.006	3	1
PANCREAS	FIGLA →	+0.032	+5.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration

SEMA4A survival (RNA) · tumor vs normal (RNA) · all SEMA4A data types