SEMA3G

Across TCGA patient cohorts, SEMA3G mutation is significantly associated with the RNA expression of many other genes, with 1,404 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA3G-associated genes across cancer lineages are MYO15B, LACTB, and FCGRT. Each is linked with SEMA3G in more than 2 cancer types. Because this analysis shows association rather than direction, both SEMA3G-to-partner and partner-to-SEMA3G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYO15B grouped by SEMA3G-low versus SEMA3G-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA3G→partner) and Y-score (partner→SEMA3G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYO15B →	-0.642	-2.300	.001	<.001	3	3
COAD	LACTB →	+0.472	+3.200	.004	.009	3	3
SKCM	FCGRT →	-0.786	-2.293	<.001	.001	3	3
SKCM	GYG2P1 →	+0.484	+1.471	.002	.007	3	3
SKCM	MSANTD3 →	+0.543	+2.096	<.001	.003	3	3
COAD	BPY2DP →	+0.104	+4.239	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,404 associations by consensus.

MYO15B by SEMA3G expression — UCEC

Explore this box plot interactively →