SEMA3G

Across TCGA cell cohorts, SEMA3G mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEMA3G-associated genes across cancer lineages are LELP1, UNCX, and NUP35. Each is linked with SEMA3G in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMA3G-to-partner and partner-to-SEMA3G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LELP1 grouped by SEMA3G-low versus SEMA3G-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA3G→partner) and Y-score (partner→SEMA3G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LELP1 →	+0.055	+3.310	<.001	<.001	3	1
BLOOD_Myeloma	UNCX →	+0.006	+4.807	<.001	.006	3	1
BLOOD_Leukemia	NUP35 →	+0.556	+3.199	.001	.007	3	1
BLOOD_Leukemia	TP53TG3D →	+0.834	+2.754	.004	.004	3	1
LARGE_INTESTINE	SCGB2A1 →	+0.543	+3.392	<.001	.006	3	1
LARGE_INTESTINE	IFITM3 →	+2.023	+3.067	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

LELP1 by SEMA3G expression — SKIN

Explore this box plot interactively →