SEMA3B-AS1

Across TCGA pan-cancer cohorts, SEMA3B-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated SEMA3B-AS1 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher SEMA3B-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SEMA3B-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and MESO show a favorable association.

BRCA, KIRC, and MESO are the cancer types where SEMA3B-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Quartile	II,III,IV	0.756	0.522	<.001	80	view →
KIRC	DFS	Median	All	0.837	0.906	.001	72	view →
MESO	OS	Tertile	All	0.558	0.274	<.001	60	view →
SKCM	DFS	Quartile	All	0.715	0.510	<.001	53	view →
UCS	DFS	Median	II,III,IV	0.528	0.190	.006	30	view →
PCPG	DFS	Tertile	All	0.778	0.963	.009	26	view →
THCA	OS	Median	IV	0.551	0.924	.006	20	view →
PRAD	DFS	Median	All	0.711	0.834	<.001	18	view →
LUAD	DFS	Tertile	IV	0.471	0.903	.005	18	view →
KIRP	DFS	Tertile	All	0.951	0.833	.001	17	view →
STAD	DFS	Median	IV	0.565	0.155	.009	12	view →
LAML	DFS	Median	All	0.593	0.322	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

SEMA3B-AS1–BRCA (OS)

Open the BRCA breakdown →