SEM1

Across TCGA patient cohorts, SEM1 protein abundance is significantly associated with the RNA expression of many other genes, with 5,850 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SEM1-associated genes across cancer lineages are RIN2, TRIM29, and BLCAP. Each is linked with SEM1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SEM1-to-partner and partner-to-SEM1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEM1 versus RIN2 in OV, with a Pearson correlation of 0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEM1→partner) and Y-score (partner→SEM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RIN2 →	+1.073	+1.276	.001	.008	3	2
BRCA	TRIM29 →	+4.030	+3.161	.004	.004	1	4
OV	BLCAP →	+1.053	+1.324	<.001	.005	3	2
LSCC	CGB7 →	+0.265	+1.824	<.001	<.001	3	2
OV	SRC →	+1.024	+1.434	.001	.001	3	2
HNSC	DDHD1 →	-0.564	-0.978	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,850 associations by consensus.

SEM1 vs RIN2 — OV

Explore this scatter interactively →