SEM1

Across TCGA cell cohorts, SEM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,692 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SEM1-associated GO terms across cancer lineages are 7-methylguanosine cap hypermethylation, Nucleoside triphosphate biosynthetic process, and Regulation of DNA replication. Each is linked with SEM1 in more than 8 cancer types. Because this analysis shows association rather than direction, both SEM1-to-partner and partner-to-SEM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 7-methylguanosine cap hypermethylation grouped by SEM1-low versus SEM1-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEM1→partner) and Y-score (partner→SEM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	7-methylguanosine cap hypermethylation →	+0.086	+0.667	<.001	.001	3	9
BLOOD_Leukemia	Nucleoside triphosphate biosynthetic process →	+0.077	+0.665	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA replication →	+0.085	+1.348	<.001	<.001	3	8
PANCREAS	snRNA modification →	+0.085	+0.709	.002	<.001	2	9
OVARY	Negative regulation of synaptic vesicle exocytosis →	+0.140	+0.646	<.001	<.001	3	8
OVARY	Malate-aspartate shuttle →	+0.090	+0.650	.002	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,692 associations by consensus.

7-methylguanosine cap hypermethylation by SEM1 expression — SKIN

Explore this box plot interactively →