SEM1

Across TCGA cell cohorts, SEM1 mutation is significantly associated with the mutation status of many other genes, with 317 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEM1-associated genes across cancer lineages are EPDR1, HSD17B2, and LAT2. Each is linked with SEM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEM1-to-partner and partner-to-SEM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EPDR1 grouped by SEM1-low versus SEM1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEM1→partner) and Y-score (partner→SEM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EPDR1 →	+5.087	+4.523	.006	.006	1	1
LARGE_INTESTINE	HSD17B2 →	+3.350	+4.584	.003	.003	1	1
LARGE_INTESTINE	LAT2 →	+4.087	+5.044	.001	.001	1	1
LARGE_INTESTINE	PHACTR3 →	+3.087	+4.392	.005	.005	1	1
LARGE_INTESTINE	RHOBTB2 →	+3.087	+4.392	.005	.005	1	1
LARGE_INTESTINE	COQ9 →	+5.087	+4.523	.006	.006	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 317 associations by consensus.

EPDR1 by SEM1 expression — LARGE_INTESTINE

Explore this box plot interactively →