SELPLG

Across TCGA patient cohorts, SELPLG mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SELPLG-associated genes across cancer lineages are MEK1, Notch1, and Caspase-8. Each is linked with SELPLG in more than 1 cancer types. Because this analysis shows association rather than direction, both SELPLG-to-partner and partner-to-SELPLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SELPLG-low versus SELPLG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SELPLG→partner) and Y-score (partner→SELPLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.398	+2.700	.015	.006	3	1
UCEC	Notch1 →	+0.157	+2.179	.013	.034	3	1
UCEC	Caspase-8 →	-0.253	-2.000	.025	.032	3	1
UCEC	Cyclin-B1 →	+0.534	+2.700	.034	.006	3	1
UCEC	Caspase-7-cleavedD198 →	+1.001	+2.000	<.001	.032	1	2
UCEC	Rad50 →	-0.283	-3.807	.009	<.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MEK1 by SELPLG expression — UCEC

Explore this box plot interactively →