SELPLG

Across TCGA cell cohorts, SELPLG RNA expression is significantly associated with the go_rna of many other GO terms, with 5,597 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SELPLG-associated GO terms across cancer lineages are Negative regulation of cytokine production, Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, and Positive regulation of canonical NF-kappaB signal transduction. Each is linked with SELPLG in more than 11 cancer types. Because this analysis shows association rather than direction, both SELPLG-to-partner and partner-to-SELPLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cytokine production grouped by SELPLG-low versus SELPLG-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SELPLG→partner) and Y-score (partner→SELPLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of cytokine production →	+0.050	+1.129	<.001	<.001	3	12
BONE	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.260	+1.628	<.001	<.001	3	11
BONE	Positive regulation of canonical NF-kappaB signal transduction →	+0.056	+1.094	<.001	<.001	3	11
LIVER	Glycosaminoglycan catabolic process →	+0.219	+1.061	<.001	<.001	2	12
SOFT_TISSUE	Macroautophagy →	+0.039	+0.589	<.001	<.001	3	11
BONE	Protein targeting to vacuole involved in autophagy →	+0.191	+1.125	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,597 associations by consensus.

Negative regulation of cytokine production by SELPLG expression — BONE

Explore this box plot interactively →