SELPLG

Across TCGA cell cohorts, SELPLG mutation is significantly associated with the drug of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SELPLG-associated genes across cancer lineages are GSK2606414, GSK2110183B, and 50869. Each is linked with SELPLG in more than 1 cancer types. Because this analysis shows association rather than direction, both SELPLG-to-partner and partner-to-SELPLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK2606414 grouped by SELPLG-low versus SELPLG-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SELPLG→partner) and Y-score (partner→SELPLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSK2606414 →	+0.421	+2.769	.030	.040	3	1
LARGE_INTESTINE	GSK2110183B →	+0.714	+2.649	.018	.046	3	1
LARGE_INTESTINE	50869 →	+0.442	+2.649	.037	.046	3	1
LARGE_INTESTINE	Sabutoclax →	+0.461	+2.769	.029	.040	3	1
LARGE_INTESTINE	Entospletinib →	+0.501	+2.646	.008	.047	1	1
LARGE_INTESTINE	GSK2276186C →	+0.563	+2.649	.014	.046	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

GSK2606414 by SELPLG expression — LARGE_INTESTINE

Explore this box plot interactively →