SELP

Across TCGA pan-cancer cohorts, SELP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SELP data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SELP mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SELP expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, CCRCC, and UCEC are the cancer types where SELP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.804	0.447	.003	16	view →
CCRCC	DFS	Quartile	II,III,IV	0.198	0.887	.024	12	view →
UCEC	DFS	Tertile	III,IV	0.232	1.000	.002	12	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	9	view →
HNSC	OS	Median	II,III,IV	0.953	1.000	.019	5	view →
LSCC	DFS	Median	All	0.907	0.464	.009	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SELP–LUAD (DFS)

Open the LUAD breakdown →