SELP

Across TCGA patient cohorts, SELP mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SELP-associated genes across cancer lineages are INPP4B, mTOR_pS2448, and PDCD4. Each is linked with SELP in more than 2 cancer types. Because this analysis shows association rather than direction, both SELP-to-partner and partner-to-SELP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by SELP-low versus SELP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SELP→partner) and Y-score (partner→SELP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.244	-2.584	.024	.010	3	3
UCEC	mTOR_pS2448 →	-0.113	-2.202	.024	.010	3	3
UCEC	PDCD4 →	-0.540	-2.575	<.001	.001	3	3
UCEC	c-Met_pY1235 →	+0.062	+1.594	.012	.010	3	3
SKCM	PKC-b-II_pS660 →	-0.222	-2.115	.017	.015	3	3
UCEC	MEK1 →	+0.271	+2.321	.027	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

INPP4B by SELP expression — UCEC

Explore this box plot interactively →