Across TCGA patient cohorts, SELENOV mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SELENOV-associated genes across cancer lineages are JNK_pT183_Y185, Ku80, and MEK1. Each is linked with SELENOV in more than 1 cancer types. Because this analysis shows association rather than direction, both SELENOV-to-partner and partner-to-SELENOV results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SELENOV→partner) and Y-score (partner→SELENOV) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.212	-2.986	.029	.037	3	1
UCEC	Ku80 →	+0.398	+3.013	.003	.019	3	1
UCEC	MEK1 →	+0.648	+3.000	.002	.036	3	1
UCEC	VHL →	-0.924	-3.000	.018	.037	3	1
UCEC	C-Raf →	+0.173	+3.000	.037	.037	3	1
UCEC	Tuberin →	+0.438	+3.000	.004	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

SELENOV survival (RNA) · tumor vs normal (RNA) · all SELENOV data types