Across TCGA patient cohorts, SELENOT mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SELENOT-associated genes across cancer lineages are A-Raf_pS299, ERK2, and FOXO3a_pS318_S321. Each is linked with SELENOT in more than 1 cancer types. Because this analysis shows association rather than direction, both SELENOT-to-partner and partner-to-SELENOT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SELENOT→partner) and Y-score (partner→SELENOT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.191	-3.321	<.001	.010	3	1
UCEC	ERK2 →	+0.350	+3.459	<.001	.005	3	1
UCEC	FOXO3a_pS318_S321 →	-0.125	-3.312	.031	.010	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.651	+3.469	.006	.002	3	1
UCEC	JNK_pT183_Y185 →	-0.272	-3.321	<.001	.010	3	1
UCEC	Ku80 →	+0.239	+1.887	.030	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

SELENOT survival (RNA) · tumor vs normal (RNA) · all SELENOT data types