Across TCGA pan-cancer cohorts, SELENOKP2 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SELENOKP2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SELENOKP2 RNA is repressed in tumor relative to normal tissue. In most cancer types SELENOKP2 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA, COAD, and KIRC are the cancer types where SELENOKP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SELENOKP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.349	<.001	7	view →
COAD	All	All	+0.235	.004	3	view →
KIRC	Female	IV	+0.165	.011	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SELENOKP2 RNA expression & survival · all SELENOKP2 data types