SELENOK

Across TCGA pan-cancer cohorts, SELENOK RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SELENOK data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher SELENOK RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SELENOK expression acts as an unfavorable survival marker, although some lineages such as LUAD and SKCM show a favorable association.

ESCA, LUAD, and ACC are the cancer types where SELENOK RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Tertile	All	0.393	0.704	<.001	98	view →
LUAD	DFS	Tertile	All	0.737	0.593	.001	77	view →
ACC	DFS	Tertile	All	0.242	0.773	<.001	52	view →
SKCM	OS	Median	All	0.425	0.247	<.001	40	view →
LGG	OS	Median	All	0.865	0.755	<.001	30	view →
COAD	DFS	Tertile	IV	0.768	0.291	.005	30	view →
LIHC	OS	Median	All	0.630	0.771	.005	22	view →
SCLC	OS	Median	All	0.455	1.000	.001	21	view →
BLCA	DFS	Quartile	II,III,IV	0.537	0.398	.012	20	view →
CHOL	DFS	Median	All	0.701	0.243	.002	18	view →
THCA	DFS	Quartile	All	0.914	0.707	<.001	12	view →
UCEC	DFS	Tertile	II,III,IV	0.881	0.756	.016	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SELENOK–ESCA (OS)

Open the ESCA breakdown →