SEL1L3

Across TCGA pan-cancer cohorts, SEL1L3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SEL1L3 data layer compared with 28 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SEL1L3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SEL1L3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

UCEC, GBM, and PDAC are the cancer types where SEL1L3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	II,III,IV	1.000	0.525	.043	8	view →
GBM	OS	Quartile	All	0.579	0.235	.006	6	view →
PDAC	OS	Quartile	III,IV	0.792	0.248	.048	4	view →
LSCC	OS	Quartile	II,III,IV	0.614	0.932	.036	4	view →
HNSC	OS	Median	All	0.823	0.940	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SEL1L3–UCEC (OS)

Open the UCEC breakdown →