SEL1L3

Across TCGA patient cohorts, SEL1L3 mutation is significantly associated with the RNA expression of many other genes, with 4,215 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEL1L3-associated genes across cancer lineages are MIR4706, ZNF330, and RPA2. Each is linked with SEL1L3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SEL1L3-to-partner and partner-to-SEL1L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4706 grouped by SEL1L3-low versus SEL1L3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEL1L3→partner) and Y-score (partner→SEL1L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR4706 →	+0.662	+3.867	<.001	.004	3	3
SKCM	ZNF330 →	+0.426	+1.616	.003	.005	3	3
COAD	RPA2 →	+0.542	+3.375	.001	.005	3	3
UCEC	EIF2B2 →	+0.330	+2.455	.001	.001	3	3
UCEC	EXOSC9 →	+0.492	+2.399	<.001	<.001	3	3
UCEC	ICE2 →	+0.446	+2.559	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,215 associations by consensus.

MIR4706 by SEL1L3 expression — BLCA

Explore this box plot interactively →