SEL1L3

Across TCGA patient cohorts, SEL1L3 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEL1L3-associated genes across cancer lineages are mTOR_pS2448, EGFR, and HER3. Each is linked with SEL1L3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SEL1L3-to-partner and partner-to-SEL1L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by SEL1L3-low versus SEL1L3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEL1L3→partner) and Y-score (partner→SEL1L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.140	-2.571	.006	.010	3	3
SKCM	EGFR →	-0.188	-2.584	.002	.001	3	2
SKCM	HER3 →	+0.377	+2.222	.016	.009	3	2
SKCM	HSP70 →	-0.514	-3.169	.010	.017	3	2
SKCM	IGFBP2 →	-0.454	-2.584	.020	.010	3	2
UCEC	Ku80 →	+0.244	+1.750	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

mTOR_pS2448 by SEL1L3 expression — UCEC

Explore this box plot interactively →