SEL1L3

Across TCGA cell cohorts, SEL1L3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,739 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SEL1L3-associated GO terms across cancer lineages are Response to endoplasmic reticulum stress, Negative regulation of hematopoietic stem cell differentiation, and GDF15-GFRAL signaling pathway. Each is linked with SEL1L3 in more than 9 cancer types. Because this analysis shows association rather than direction, both SEL1L3-to-partner and partner-to-SEL1L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to endoplasmic reticulum stress grouped by SEL1L3-low versus SEL1L3-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEL1L3→partner) and Y-score (partner→SEL1L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Response to endoplasmic reticulum stress →	+0.062	+1.556	<.001	<.001	3	10
LUNG_SCLC	Negative regulation of hematopoietic stem cell differentiation →	+0.159	+1.677	<.001	.001	3	10
STOMACH	GDF15-GFRAL signaling pathway →	+1.480	+2.559	<.001	<.001	3	9
BLOOD_Myeloma	Establishment of protein localization to endoplasmic reticulum →	+0.089	+2.359	.007	.007	3	8
BLOOD_Lymphoma	Serotonin secretion →	+1.151	+2.365	<.001	<.001	3	8
BLOOD_Lymphoma	Serotonin production involved in inflammatory response →	+1.151	+2.365	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,739 associations by consensus.

Response to endoplasmic reticulum stress by SEL1L3 expression — OVARY

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