SECTM1

Across TCGA pan-cancer cohorts, SECTM1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SECTM1 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SECTM1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SECTM1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where SECTM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.590	0.920	.003	24	view →
PDAC	OS	Median	III,IV	0.193	0.798	.024	6	view →
LUAD	OS	Median	III,IV	0.332	0.699	.042	2	view →
HNSC	DFS	Median	IV	1.000	0.862	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SECTM1–LSCC (OS)

Open the LSCC breakdown →