SECTM1

Across TCGA cell cohorts, SECTM1 mutation is significantly associated with the drug of many other genes, with 36 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SECTM1-associated genes across cancer lineages are Cytarabine, Methotrexate, and Niraparib. Each is linked with SECTM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SECTM1-to-partner and partner-to-SECTM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytarabine grouped by SECTM1-low versus SECTM1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SECTM1→partner) and Y-score (partner→SECTM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Cytarabine →	+1.181	+2.877	<.001	.020	3	1
LARGE_INTESTINE	Methotrexate →	+1.060	+2.807	.006	.046	3	1
LARGE_INTESTINE	Niraparib →	+0.443	+2.900	.005	.015	3	1
LARGE_INTESTINE	Fulvestrant →	+0.316	+2.710	.044	.027	3	1
LARGE_INTESTINE	N24798-49-A1 →	+0.249	+2.807	.032	.045	3	1
LARGE_INTESTINE	UNC0642 →	+0.217	+2.658	.020	.043	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Cytarabine by SECTM1 expression — LARGE_INTESTINE

Explore this box plot interactively →