SEC63

Across TCGA patient cohorts, SEC63 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,169 significant associations in total. THCA shows the largest number of these associations.

The most reproducible SEC63-associated GO terms across cancer lineages are Nuclear-transcribed mRNA catabolic process, Ribosome-associated ubiquitin-dependent protein catabolic process, and RNA 3'-end processing. Each is linked with SEC63 in more than 33 cancer types. Because this analysis shows association rather than direction, both SEC63-to-partner and partner-to-SEC63 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear-transcribed mRNA catabolic process grouped by SEC63-low versus SEC63-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC63→partner) and Y-score (partner→SEC63) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Nuclear-transcribed mRNA catabolic process →	+0.064	+0.441	<.001	<.001	3	34
SCLC	Ribosome-associated ubiquitin-dependent protein catabolic process →	+0.151	+0.897	<.001	<.001	3	34
ESCA	RNA 3'-end processing →	+0.082	+0.490	<.001	<.001	3	34
SCLC	mRNA 3'-end processing →	+0.074	+0.468	<.001	.001	3	34
DLBC	Protein modification by small protein removal →	+0.082	+0.981	<.001	<.001	3	34
DLBC	Golgi ribbon formation →	+0.077	+0.695	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,169 associations by consensus.

Nuclear-transcribed mRNA catabolic process by SEC63 expression — ESCA

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