SEC63

Across TCGA patient cohorts, SEC63 protein abundance is significantly associated with the RNA expression of many other genes, with 14,072 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SEC63-associated genes across cancer lineages are ZNF484, SPARCL1, and PLSCR4. Each is linked with SEC63 in more than 7 cancer types. Because this analysis shows association rather than direction, both SEC63-to-partner and partner-to-SEC63 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEC63 versus ZNF484 in BRCA, with a Pearson correlation of -0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC63→partner) and Y-score (partner→SEC63) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF484 →	-0.761	-0.516	<.001	<.001	3	8
UCEC	SPARCL1 →	-1.085	-0.343	<.001	<.001	3	7
GBM	PLSCR4 →	-0.890	-0.359	<.001	<.001	3	7
UCEC	TRMO →	-0.545	-0.373	.001	<.001	3	7
HNSC	XPA →	-0.607	-0.259	<.001	<.001	3	7
CCRCC	ZNF189 →	-0.928	-0.319	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,072 associations by consensus.

SEC63 vs ZNF484 — BRCA

Explore this scatter interactively →