SEC63

Across TCGA patient cohorts, SEC63 mutation is significantly associated with the RNA expression of many other genes, with 3,634 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC63-associated genes across cancer lineages are RNU6ATAC2P, SNORD90, and MYO19. Each is linked with SEC63 in more than 2 cancer types. Because this analysis shows association rather than direction, both SEC63-to-partner and partner-to-SEC63 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6ATAC2P grouped by SEC63-low versus SEC63-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC63→partner) and Y-score (partner→SEC63) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6ATAC2P →	+0.297	+5.506	.002	.005	3	3
LUSC	SNORD90 →	+0.294	+3.006	<.001	.006	3	3
UCEC	MYO19 →	+0.397	+2.152	.001	.002	3	2
READ	LINC00836 →	+0.078	+5.653	<.001	.003	3	2
BLCA	LRRC37A13P →	+0.195	+4.363	<.001	<.001	3	2
BRCA	RN7SL667P →	+0.124	+5.540	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,634 associations by consensus.

RNU6ATAC2P by SEC63 expression — BRCA

Explore this box plot interactively →