SEC63

Across TCGA cell cohorts, SEC63 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,501 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SEC63-associated GO terms across cancer lineages are SRP-dependent cotranslational protein targeting to membrane, Cotranslational protein targeting to membrane, and 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process. Each is linked with SEC63 in more than 17 cancer types. Because this analysis shows association rather than direction, both SEC63-to-partner and partner-to-SEC63 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRP-dependent cotranslational protein targeting to membrane grouped by SEC63-low versus SEC63-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC63→partner) and Y-score (partner→SEC63) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SRP-dependent cotranslational protein targeting to membrane →	+0.156	+0.825	.001	.001	3	18
OESOPHAGUS	Cotranslational protein targeting to membrane →	+0.198	+1.001	<.001	.002	3	16
LUNG_NSCLC_LUSC	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process →	+0.145	+1.042	.002	<.001	3	14
LUNG_SCLC	Post-translational protein targeting to membrane, translocation →	+0.095	+0.635	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of formation of translation preinitiation complex →	+0.079	+0.702	.002	.007	3	13
UPPER_AERODIGESTIVE_TRACT	Negative regulation of formation of translation preinitiation complex →	+0.079	+0.702	.002	.007	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,501 associations by consensus.

SRP-dependent cotranslational protein targeting to membrane by SEC63 expression — OESOPHAGUS

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