SEC62

Across TCGA pan-cancer cohorts, SEC62 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SEC62 data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SEC62 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEC62 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

CCRCC, UCEC, and PDAC are the cancer types where SEC62 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.562	0.898	.004	33	view →
UCEC	DFS	Median	All	0.762	0.951	.003	16	view →
PDAC	DFS	Quartile	II,III,IV	0.343	0.649	.010	11	view →
LSCC	OS	Quartile	II,III,IV	0.565	0.893	.013	10	view →
HNSC	DFS	Quartile	All	0.895	0.716	.028	7	view →
LUAD	OS	Tertile	II,III,IV	0.886	0.537	.049	2	view →
GBM	OS	Median	All	0.677	0.835	.020	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SEC62–CCRCC (DFS)

Open the CCRCC breakdown →