SEC62

Across TCGA patient cohorts, SEC62 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC62-associated genes across cancer lineages are EGFR_pY1068, p90 RSK, and Shc_pY317. Each is linked with SEC62 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC62-to-partner and partner-to-SEC62 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SEC62-low versus SEC62-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC62→partner) and Y-score (partner→SEC62) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.330	-3.000	.022	.037	3	1
UCEC	p90 RSK →	+0.241	+3.013	.029	.019	3	1
UCEC	Shc_pY317 →	-0.247	-3.000	.004	.037	3	1
UCEC	TSC1 →	-0.288	-3.000	.003	.037	3	1
UCEC	Rab11 →	-0.187	-3.000	.025	.037	1	1
UCEC	Rad50 →	-0.344	-3.000	.014	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

EGFR_pY1068 by SEC62 expression — UCEC

Explore this box plot interactively →