SEC62

Across TCGA cell cohorts, SEC62 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,490 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SEC62-associated GO terms across cancer lineages are Post-translational protein targeting to membrane, translocation, Protein exit from endoplasmic reticulum, and Endoplasmic reticulum to cytosol transport. Each is linked with SEC62 in more than 17 cancer types. Because this analysis shows association rather than direction, both SEC62-to-partner and partner-to-SEC62 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Post-translational protein targeting to membrane, translocation grouped by SEC62-low versus SEC62-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC62→partner) and Y-score (partner→SEC62) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Post-translational protein targeting to membrane, translocation →	+0.154	+0.919	<.001	<.001	3	18
SOFT_TISSUE	Protein exit from endoplasmic reticulum →	+0.123	+0.819	<.001	<.001	3	13
SOFT_TISSUE	Endoplasmic reticulum to cytosol transport →	+0.115	+0.594	.001	.006	3	12
SOFT_TISSUE	Retrograde protein transport, ER to cytosol →	+0.115	+0.594	.001	.006	3	12
SOFT_TISSUE	Cellular response to water stimulus →	+0.094	+0.505	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Cellular response to hydrostatic pressure →	+0.111	+0.736	.006	.007	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,490 associations by consensus.

Post-translational protein targeting to membrane, translocation by SEC62 expression — OESOPHAGUS

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