SEC62

Across TCGA cell cohorts, SEC62 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SEC62-associated genes across cancer lineages are EPB42, PRAMEF8, and SIGLEC14. Each is linked with SEC62 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC62-to-partner and partner-to-SEC62 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EPB42 grouped by SEC62-low versus SEC62-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC62→partner) and Y-score (partner→SEC62) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	EPB42 →	+0.024	+4.196	.002	.002	3	1
SKIN	PRAMEF8 →	+0.156	+3.793	<.001	.007	3	1
SKIN	SIGLEC14 →	+0.066	+3.777	.002	.007	3	1
SKIN	NCR2 →	+0.012	+4.437	<.001	.004	3	1
BLOOD_Leukemia	NPFFR1 →	+0.011	+4.037	.003	.004	3	1
BLOOD_Leukemia	KRT6C →	+0.021	+4.037	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

EPB42 by SEC62 expression — SKIN

Explore this box plot interactively →