SEC61B

Across TCGA pan-cancer cohorts, SEC61B Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SEC61B data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SEC61B Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEC61B expression acts as an unfavorable survival marker.

CESC and KIRC are the cancer types where SEC61B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.173	0.740	.003	12	view →
KIRC	OS	Median	All	0.178	0.655	.042	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SEC61B–CESC (DFS)

Open the CESC breakdown →