SEC61B

Across TCGA patient cohorts, SEC61B protein abundance is significantly associated with the RNA expression of many other genes, with 12,245 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SEC61B-associated genes across cancer lineages are SPTBN1, EPB41L5, and RPN1. Each is linked with SEC61B in more than 5 cancer types. Because this analysis shows association rather than direction, both SEC61B-to-partner and partner-to-SEC61B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEC61B versus SPTBN1 in UCEC, with a Pearson correlation of -0.24.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC61B→partner) and Y-score (partner→SEC61B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPTBN1 →	-0.450	-0.364	.007	.002	3	6
CCRCC	EPB41L5 →	-0.538	-0.320	<.001	.003	3	5
BRCA	RPN1 →	+0.364	+0.397	.007	.002	3	5
UCEC	MYO9A →	-0.439	-0.417	.002	.001	3	5
COAD	CEP68 →	-0.498	-0.257	.003	<.001	3	5
COAD	FKBP11 →	+0.490	+0.194	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,245 associations by consensus.

SEC61B vs SPTBN1 — UCEC

Explore this scatter interactively →