SEC61B

Across TCGA patient cohorts, SEC61B mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC61B-associated genes across cancer lineages are MIR7976, SMIM4, and MIR4672. Each is linked with SEC61B in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC61B-to-partner and partner-to-SEC61B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR7976 grouped by SEC61B-low versus SEC61B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC61B→partner) and Y-score (partner→SEC61B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR7976 →	+0.458	+2.868	.001	.006	3	1
UCEC	SMIM4 →	+0.695	+3.201	.001	.009	3	1
UCEC	MIR4672 →	+0.513	+2.626	<.001	.006	3	1
UCEC	RNU6-879P →	+0.452	+2.581	.007	.007	3	1
UCEC	TRAV8-6 →	+0.894	+3.201	<.001	.009	3	1
UCEC	TRAJ31 →	+1.053	+2.872	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

MIR7976 by SEC61B expression — UCEC

Explore this box plot interactively →