SEC61B

Across TCGA patient cohorts, SEC61B mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC61B-associated genes across cancer lineages are Notch1, Bax, and p90 RSK_pT359_S363. Each is linked with SEC61B in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC61B-to-partner and partner-to-SEC61B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SEC61B-low versus SEC61B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC61B→partner) and Y-score (partner→SEC61B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.269	+3.013	<.001	.018	3	1
UCEC	Bax →	+0.302	+3.169	.021	.020	3	1
UCEC	p90 RSK_pT359_S363 →	-0.219	-3.169	.049	.020	2	1
UCEC	PCNA →	+0.331	+3.169	.005	.020	2	1
UCEC	EGFR_pY1068 →	-0.295	-3.169	.032	.020	1	1
UCEC	PRDX1 →	+0.343	+3.169	.002	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Notch1 by SEC61B expression — UCEC

Explore this box plot interactively →